Abstract
BackgroundPathogenic strains of Staphylococcus aureus can cause several diseases including septicemia and endocarditis, in spite of being a commensal species of the human microbiota. The current drug resistance of S. aureus raises the need for new antimicrobials, and natural products represent a feasible source for prospection of such compounds, due to features including the diversity of structures and mechanisms of action. Here, we provide evidence of the antimicrobial activity of methanolic of Psidium guajava and Passiflora edulis pulps against planktonic cells and biofilms of clinical isolates of S. aureus.ResultsThe extracts were effective against the strains in concentrations up to 7.81 and 250 μg/mL for planktonic cells and biofilms, respectively. Antagonistic interactions of the extracts to antimicrobial drugs were observed. The pulps caused no cytotoxic effects on BGM cells. GC-MS analysis found relevant molecules, and UPLC analysis suggested the presence of flavonoids. To the best of our knowledge, this is the first antibiofilm evidence of such extracts.ConclusionThe extracts seem to be safe and effective enough for more studies aiming at exploring isolated antimicrobial molecules using in vivo models for the treatment of staphylococcal diseases.
Highlights
Pathogenic strains of Staphylococcus aureus can cause several diseases including septicemia and endocarditis, in spite of being a commensal species of the human microbiota
Chemical analyses ultra-performance liquid chromatography (UPLC) analysis confirmed the presence of phenolic compounds in the sample, as peaks were detected at 280 nm Antimicrobial parameter
Here we described the antimicrobial and antibiofilm activities of the methanolic extracts obtained from industrially manufactured P. guajava and P. edulis pulps against clinical isolates of S. aureus, to the best of our knowledge, for the first time
Summary
Pathogenic strains of Staphylococcus aureus can cause several diseases including septicemia and endocarditis, in spite of being a commensal species of the human microbiota. We provide evidence of the antimicrobial activity of methanolic of Psidium guajava and Passiflora edulis pulps against planktonic cells and biofilms of clinical isolates of S. aureus. Psidium guajava is common in tropical and subtropical countries, and the fruit (guava) is used for artisanal and industrial manufacturing of jellies, sweets, powder fibers, and juice [6, 7]. Guava juice is specially appreciated, and pulps are prepared in order to allow the consumption of the juice throughout the year, avoiding seasonal influences on the availability of fruit [11, 12].
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