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Abstract
The sensitivity and specificity of methods to detect anti-basal ganglia antibodies (ABGA) in Sydenham’s chorea were determined in a study at the Institute of Neurology, Queen Square; Great Ormond Street Hospital for Children; Royal Free and University College Hospital Medical School, London, UK; and Federal University of Minas Gerais, Brazil.
Highlights
The sensitivity and specificity of methods to detect anti-basal ganglia antibodies (ABGA) in Sydenham's chorea were determined in a study at the Institute of Neurology, Queen Square; Great Ormond Street Hospital for Children; Royal Free and University College Hospital Medical School, London, UK; and Federal University of Minas Gerais, Brazil
In acute SC, a sensitivity of 95% and specificity of 93% were obtained with ABGA ELISA, while WB and IF had a sensitivity of 100% and specificity of 93%
Anti-basal ganglia antibodies are reported in Sydenham's chorea and pediatric autoimmune neuropsychiatric disorder associated with streptococcus (PANDAS)
Summary
SIMPLIFIED CLASSIFICATION OF FOCAL CORTICAL DYSPLASIA Sections of cortex from 52 of 224 (23%) patients with cortical dysplasia, operated on for drug-resistant partial epilepsy, were retrospectively re-examined histologically at Niguarda Hospital, and Istituto Nazionale Neurologico 'C. The sensitivity and specificity of methods to detect anti-basal ganglia antibodies (ABGA) in Sydenham's chorea were determined in a study at the Institute of Neurology, Queen Square; Great Ormond Street Hospital for Children; Royal Free and University College Hospital Medical School, London, UK; and Federal University of Minas Gerais, Brazil. Samples from 20 patients with acute SC, 16 with persistent SC, control samples from 16 with rheumatic fever (RF), and 11 healthy pediatric volunteers were tested with ELISA and Western immunoblotting (WB) methods to detect ABGA and compared these assays to immunofluorescent (IF) methods.
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