Abstract
Objective: In this study, it was hypothesized that sol-gel silver coated titanium implants showed a better antibacterial activity compared to standard titanium implants in contaminated surgical fields. Material and Methods: Twenty four New Zelland Albino rabbits were used in the experiment. Right knees of the rabbits were determined as the control group and left knees were determined as the experiment group. Total knee replacement arthroplasty was performed by using a custom made titanium implant the control group. In the experiment group the same procedure was performed by using sol-gel antibacterial silver coated titanium implants. Following implantation, both groups were inoculated with bacterial suspensions containing standardised bacterial loads of S. aureus and P. aeruginosa. Animals were observed for general condition, body temperature, weight and clinical signs of implant infection for 12 weeks. Clinical signs of infection were further evaluated with microbiological tests. Results: Total infection rates, S. aureus-specific infection rates and P. aeruginosa-specific infection rates were significantly lower in sol-gel silver coated titanium implants. No statistically significant difference was found between the groups in terms of subclinical infection rates. Conclusion: We concluded that sol-gel silver coating of the titanium implants was effective against two common agents causing implant infections.
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