Abstract
The aim of present study was to explore the antibacterial potential of silver nanoparticles (AgNPs) against multidrug-resistant (MDR) non-fermenting Gram negative bacterial (NFGNB) strains. Total 457 strains of NFGNB isolated from 13954 blood samples showed identification of 68.05% isolates as MDR. The most commonly reported MDR strains included Acinetobacter spp. (73.63%), Pseudomonas spp. (24.43%), and Stenotrophomonas maltophilia (1.92%). Using representative MDR and reference strains, antibacterial potential of AgNPs was evaluated. AgNPs were chemically synthesized and characterized by UV–vis, Fourier transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). Diameter of inhibition zone was measured from 10 to 21 mm and 12 to 23 mm with AgNPs (6.25 to 50 μg/mL) for test and reference strains respectively. Against representative Pseudomonas aeruginosa MDR isolate, MIC and MBC of AgNPs were found as 3.12 and 12.5 μg/mL, respectively. Chemically synthesized AgNPs shows the greater antibacterial efficacy for their future applications to treat infections caused by MDR strains.
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