Abstract
Background: Fusobacterium nucleatum is a common bacterial in root canal with pulp necrosis and periradicular lesion. A way to eliminate these bacteria from root canal is by root canal irrigation. Root canal irrigation materials that are widely used nowadays has many shortcomings. The pericarp of mangosteen (Garcinia mangostana L) has antibacterial potency. Therefore mangosteen pericarp can be an alternative material which could inhibit and bactericidal function to Fusobacterium nucleatum. Purpose: The aim of this study was to determine the antibacterial potency of mangosteen pericarp extract (Garcinia Mangostana L.) against Fusobacterium nucleatum. Methods: This study was laboratory experimental with pos-test only control group design. A microdilution method was used to determine minimum inhibitory concentration and minimum bactericidal concentration by colony counting bacteriae in Tryptone Soya Agar (TSA) media with drop plate technique. Growth of bacterial colonies in TSA is calculated manually in colony forming unit (CFU/ml). Results: Bacterial colonies growth at concentration 0.78% was 90% less than positive control group and there were no bacterial colonies growth at concentration 0.975%. Conclusion: The Minimum Inhibitory Concentration (MIC) of mangosteen pericarp against Fusobacterium nucleatum was at 0,78% concentration and the Minimum Bactericidal Concentration (MBC) was at 0.975% concentration.
Highlights
Dental and oral health problems are still a problem
This study was conducted to determine the antibacterial potency of mangosteen pericarp extracts against Fusobacterium nucleatum
The antibacterial potency of mangosteen pericarp extracts against the bacteria Fusobacterium nucleatum was measured by observing the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC)
Summary
Dental and oral health problems are still a problem. Based on the 2007 Riskesdas data, 75% of Indonesia’s population has a history of dental caries with a severity of teeth (DMF-T index) of 5 teeth per person. Untreated caries can cause bacteria to invade the pulp, resulting in an inflammatory response that will continue to become necrotic. According to study on the identification of microorganisms in root canals with exposed pulp due to caries and periradicular lesions, it was found that the most bacteria in these canals are true anaerobic bacteria.[1] One of the microorganisms that often cause damage to the pulp is Fusobacterium spp.[2]. Fusobacterium nucleatum is a common bacterial in root canal with pulp necrosis and periradicular lesion. Mangosteen pericarp can be an alternative material which could inhibit and bactericidal function to Fusobacterium nucleatum. Purpose: The aim of this study was to determine the antibacterial potency of mangosteen pericarp extract (Garcinia Mangostana L.) against Fusobacterium nucleatum. Conclusion: The Minimum Inhibitory Concentration (MIC) of mangosteen pericarp against Fusobacterium nucleatum was at 0,78% concentration and the Minimum Bactericidal Concentration (MBC) was at 0.975% concentration
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