Antibacterial phenalenone derivatives from marine-derived fungus Pleosporales sp. HDN1811400

Abstract

Three new phenalenone derivatives, namely peniciphenalenins G − L (1–3), together with two related compounds (4 and 5), were isolated from the marine sediment-derived fungus Pleosporales sp. HDN1811400 guided by HPLC-UV profile. Structures including absolute configurations were elucidated by detailed spectroscopic analyses, DFT calculations as well as chemical method. Peniciphenalenin G (1) represents the first example of chlorinated acenaphthenquinone derivative, and compounds 1, 2, 4, and 5 showed broad antibacterial activities with the best MIC value of 6.25 μM against MRSA.