Abstract
A series of of di- and triorganotin(IV) complexes of monoisopropyl and monomethyl maleate and monoisopropyl and triphenlymethyl glutarate have been synthesized and characterized by 1 H- 13 C- 119 Sn-NMR, UV, IR and Mass spectrometry. The spectroscopic investigation demonstrated that the carboxylate group acts as a bidentate ligand in diorganotin(IV) and as a monodentate ligand in triorganotin(IV) compounds. Biological evaluation against various microorganisms indicate that the diorganotin(IV) complexes are slightly less reactive than triorganotin(IV) complexes.
Highlights
There have been several reports dealing with the impact of organotin chemistry in the biosphere.1,2 Organotin compounds show a large spectrum of biological activity but are mainly used commercially as industrial and agricultural biocides because of their antifungal properties.3 On the one hand some organotins are currently being investigated for antitumur activity 4 while on the other hand some R3SnL derivatives (L = monodentate or bidentate ligand) are highly toxic,5-7 and diorganotin(IV) derivatives like diethyltin(IV) and dibutyltin(IV) carboxylates are known antitumor agents
Different carboxylate ligands were prepared by treating maleic anhydride and glutaric anhydride with different alcohols
The reactions of dibutyltin(IV) oxide with carboxylate ligands in a toluene-ethanol (3:1, v/v) mixture afforded the complexes in a 1:2 molar ratio with the azeotropical removal of water
Summary
The reactions of dibutyltin(IV) oxide with carboxylate ligands in a toluene-ethanol (3:1, v/v) mixture afforded the complexes in a 1:2 molar ratio with the azeotropical removal of water. The spectra of the ligands and their complexes were recorded in absolute ethanol.
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