Abstract
Diabetic foot ulcer (DFU) is a chronic wound frequently delayed from severe infection. Wound dressing provides an essential barrier between the ulcer and the external environment. This review aimed to analyse the effectiveness of antibacterial collagen-based dressing for DFU treatment in a clinical setting. An electronic search in four databases, namely, Scopus, PubMed, Ovid MEDLINE(R), and ISI Web of Science, was performed to obtain relevant articles published within the last ten years. The published studies were included if they reported evidence of (1) collagen-based antibacterial dressing or (2) wound healing for diabetic ulcers, and (3) were written in English. Both randomised and non-randomised clinical trials were included. The search for relevant clinical studies (n) identified eight related references discussing the effectiveness of collagen-based antibacterial wound dressings for DFU comprising collagen impregnated with polyhexamethylene biguanide (n = 2), gentamicin (n = 3), combined-cellulose and silver (n = 1), gentian violet/methylene blue mixed (n = 1), and silver (n = 1). The clinical data were limited by small sample sizes and multiple aetiologies of chronic wounds. The evidence was not robust enough for a conclusive statement, although most of the studies reported positive outcomes for the use of collagen dressings loaded with antibacterial properties for DFU wound healing. This study emphasises the importance of having standardised clinical trials, larger sample sizes, and accurate reporting for reliable statistical evidence confirming DFU treatment efficiency.
Highlights
Diabetes mellitus (DM) presents a large social, financial, and health system burden globally; it is estimated to affect 700 million people by 2045 [1,2]
(1) address treating a diabetic population, (2) describe antibacterial and collagen-containing porous dressings, or (3) address wound healing outcomes according to the inclusion and exclusion criteria
Legend: (X) inadequate; (Y) adequate; (?) unclear; and (N/A) not applicable. The findings from this evidence-based review reported a trend of healing rate incrementation using collagen dressing loaded with antimicrobial components for Diabetic foot ulcer (DFU)
Summary
Diabetes mellitus (DM) presents a large social, financial, and health system burden globally; it is estimated to affect 700 million people by 2045 [1,2]. A common complication of DM is the slow or non-healing of wounds, in the lower extremity. Polymers 2020, 12, 2168 chronic wound resulting from the interplay of several factors either directly or indirectly caused by the hyperglycaemic condition. The abnormally high sugar level in the blood can result in poor blood circulation, prolonged inflammation, signalling factors irregularities, and high susceptibility to infection [5]. These factors disrupt the normal wound healing phases and form a feedback cycle that will eventually worsen the existing condition
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