Abstract
Microbial populations in the gastrointestinal tracts of broiler chicken can be modulated by herbal additives that contained phytochemical substances. Essential oils (EOs) have potential phytochemical compounds but are lipophilic and have low solubility in water. Therefore, self-nanoemulsifying drug delivery system (SNEDDS) might be one of the formulation strategies to improve the solubility of essential oils. In this study, the anti-bacterial activity of Cymbopogon citratus and Amomum compactum EOs by SNEDDS was conducted using disc diffusion method on Escherichia coli and Salmonella typhimurium. Inhibition zone was found on both pure EOs and SNEDDS formulations. SNEDDS formulations of C. citratus and A. compactum EOs were effective against E. coli and S. typhimurium (P<0.05). C. citratus essential oil has the highest inhibition zone when compared to the other formulations, followed by A. compactum essential oil. On the other hand, SNEDDS formula of C. citratus and A. compactum essential oil showed similar antibacterial activity as tetracycline and penicillin antibiotics in inhibiting the growth of E. coli and S. typhimurium. It can be concluded that the use of SNEDDS formula of essential oil would be useful to reduce the population of pathogen in the intestine of poultry.
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