Antibacterial, Cytotoxic Studies and Characterization of Some Newly Synthesized SymmetricalN3,N3′-Bis(disubstituted)isophthalyl-bis(thioureas) and Their Cu(II) and Ni(II) Complexes

Muhammad Jamil,Umer Rashid,Muhammad Asim Farid,Saiful Islam,Nasir Rasool,Muhammad Zubair

doi:10.1155/2013/789743

Muhammad Jamil, Umer Rashid + Show 4 more

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https://doi.org/10.1155/2013/789743

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Abstract

A series of some novelN3,N3′-bis(disubstituted)isophthalyl-bis(thioureas) compounds with general formula [C6H4·{CONHCSNHR}2], where R = 2-ClC6H4S (L1), 3,5-(Cl)2C6H3(L2), 2,4-(Cl)2C6H3(L3), 2,5-(Cl)2C6H3(L4), and 2-NH2C6H4(L5), and their Cu(II) and Ni(II) complexes (C1–C10) have been synthesized. These compounds (L1–L5) and their metal(II) complexes (C1–C10) have been characterized by elemental analysis, infrared spectroscopy,1H NMR and13C NMR spectroscopy, magnetic moments, and electronic spectral measurements. The ligands are coordinated to metal atom in a bidentate pattern producing a neutral complex of the type [ML]2. These compounds (L1–L5) and their metal(II) complexes (C1–C10) were also screened for their antibacterial and cytotoxic activities.

Highlights

Thioureas, an emerging class of compounds, were first synthesized by Neucki [1]
Reported [16] some dithiourea derivatives exhibited cytotoxicity against various cancer cells, and one of these indicated best inhibition activities against KB and CNE2 with IC50 values of 10.72 and 9.91 micrometer, respectively. In view of these results, our interest increased in the synthesis of some new bis(thiourea) derivatives which were characterized by spectroscopic techniques such as FTIR, 1H NMR, and 13C NMR
The isophthalyl isothiocyanate 3 are useful synthetic building blocks which may be efficiently used for the synthesis of N,N󸀠-disubstituted thioureas and benzenedicarbonyl bisthioureas [15]

Summary

Introduction

An emerging class of compounds, were first synthesized by Neucki [1]. Thiourea derivatives hold broad range of applications in the field of medicine, agriculture, and analytical chemistry. Reported [16] some dithiourea derivatives exhibited cytotoxicity against various cancer cells, and one of these indicated best inhibition activities against KB and CNE2 with IC50 values of 10.72 and 9.91 micrometer, respectively. In view of these results, our interest increased in the synthesis of some new bis(thiourea) derivatives which were characterized by spectroscopic techniques such as FTIR, 1H NMR, and 13C NMR. These derivatives are stable and contain at least two potential donor atoms as O and S.

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