Abstract
A bioactive compound was isolated from ethyl acetate extract of the marine sponge-derived fungus Aspergillus sydowii DC08. The compound's structural details were determined based on the study of nuclear magnetic resonance spectroscopy and mass spectrometric data. p-Iodonitrotetrazolium chloride (INT), a marker of bacterial growth, was used in the microdilution assay to assess the isolated compound's antibacterial efficacy. The isolated chemical was identified as sterigmatocystin (1) using spectroscopic data. This compound showed moderate activity against some pathogenic bacteria. The Minimum Inhibitory Concentration (MIC) values for this substance were 64, 128, 16, 32, and 32 µg/mL for Methicillin-Resistant Staphylococcus aureus (MRSA), Multi-Drug Resistant Pseudomonas aeruginosa (MDRPA), Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, respectively.
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