Abstract
In this study, zinc oxide (ZnO) nanorod arrays as antibiotic agent carriers were grown on polyetheretherketone (PEEK) substrates using a chemical synthesis method. With the concentration of ammonium hydroxide in the precursor solution kept at 4 M, ZnO nanorod arrays with diameters in the range of 100–400 nm and a loading density of 1.7 mg/cm2 were grown onto the PEEK substrates. Their drug release profiles and the antibacterial properties of the antibiotic agent/ZnO/PEEK samples in the buffer solution were investigated. The results showed that the concentrations of antibiotic agents (ampicillin or vancomycin) released from the samples into the buffer solution were higher than the value of minimum inhibitory concentration of 90% for Staphylococcus aureus within the 96 h test. The bioactivities of ampicillin and vancomycin on substrates also showed around 40% and 80% on the Staphylococcus aureus, respectively. In the antibacterial activity test, sample with the suitable loading amount of antibiotic agent had a good inhibitory effect on the growth of Staphylococcus aureus.
Highlights
Applications of biomaterials with suitable antibaterial properties have been employed for the treatments of many diseases and clinical conditions that are incurable today
For the determinations of optimal parameters for Zinc oxide (ZnO) nanorod arrays grown on PEEK sample, we used the glass substrate for the preparation of ZnO nanorod arrays, which was the same as those used in the literature [34]
We developed a simple and low-cost method for the preparation of ZnO nanorod arrays on the PEEK substrate for possible application in biomaterials
Summary
Applications of biomaterials with suitable antibaterial properties have been employed for the treatments of many diseases and clinical conditions that are incurable today. Zinc oxide (ZnO) is a traditional metal oxide that is non-toxic with a high melting point, good thermal stability„ low manufacturing costs, and good antibacterial property [6,7,8] Various methods such as chemical vapor deposition [9], magnetic sputtering [10], hydrothermal reaction [11], and the template method [12] have been employed for the preparation of metal oxide thin films such as ZnO or TiO2 with 2D microstructures for the applications of optical-electronic devices [12], catalysts [6], photo-active layers in the solar cells [5], and the improvement of the sample’s antibacterial properties [13,14,15,16,17,18,19,20,21,22,23]. The surface morphology of the ZnO sample has to be remodified in order to obtain good antibacterial properties and good attachments of bone cells. Their results showed the size distributions of ZnO particles in the range of 20–120 nm through the control of water content in the solution of zinc
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