Abstract
BackgroundAntibacterial, immunomodulatory and antioxidant properties of aerial parts of Barleria lupulina Lindl were investigated in the present communication.MethodsThe antibacterial, antioxidant and immunomodulatory properties of B. lupulina (methanol soluble leaf and stem extracts) was analyzed by minimum inhibitory concentration, total phenolic contents, DPPH radical scavenging activity, determination of toxicity, hemagglutination antibody titre, delayed type hypersensitivity and neutrophil adhesion test, respectively.ResultsMethanol soluble leaf extract (MLE) contains more soluble bioactive compounds inhibiting the growth of five bacterial pathogens viz., Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Salmonella typhi even at MICs of 1.25 and 2.5 mg/mL. Aqueous stem extract (ASE) was least effective while MLE was highly effective in inhibiting the growth and survival of bacterial pathogens. While testing the effect of these extracts in animal model, no mortality of albino rats was recorded by using MLE and MSE at the concentrations from 200 to 600 mg/kg of their body weight. The MLE showed significant result in agglutination reaction and induced paw edema volumes when compared with untreated group (control). Both MLE and MSE extracts significantly increased neutrophil adhesion with increase in doses of extracts. MLE was found to have more potent immune-stimulant properties than the MSE. High phenolic contents were found in MSE while lowest IC50 values were found in MLE in term of DPPH radical scavenging activity.ConclusionsMethanol soluble leaf and stem extract of Barleria lupulina contains antibacterial, antioxidants and immunomodulating phytochemical compounds that was effective for antibacterial, antioxidant and immunomodulatory properties. These may be used as synthetic drug.
Highlights
Antibacterial, immunomodulatory and antioxidant properties of aerial parts of Barleria lupulina Lindl were investigated in the present communication
Methanol soluble leaf and stem extract of Barleria lupulina contains antibacterial, antioxidants and immunomodulating phytochemical compounds that was effective for antibacterial, antioxidant and immunomodulatory properties
Methanol soluble leaf extract (MLE) consisted of alkaloids, saponins, tannins and flavonoids and proteins, whereas aqueous leaf extract (ALE) consisted of saponins, flavonoids and sugars
Summary
Antibacterial, immunomodulatory and antioxidant properties of aerial parts of Barleria lupulina Lindl were investigated in the present communication. An immunomodulators may be defined as a substance which biologically can stimulate, suppress or modulate any of the components of the immune system or immune response. The essence of immunomodulation or phytochemical or biologically. Kumari et al BMC Complementary and Alternative Medicine (2017) 17:484 interest to innovative scientist working on infectious diseases or to improve immune system of human beings. There are several medicinal plants are employed in different system of medicine throughout the world to improve the various immunological disorders in which Barleria (genus) is the one of the best that played important role in this concern. The genus Barleria is a large, polymorphic, widespread genus of herbs, shrubs and rarely climbers comprising approximately 300 species distributed worldwide. The greatest representation of this genus occurs in Africa and Asia, with its greatest centre of diversity in tropical East Africa
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