Abstract
Schiff bases have been widely researched in vitro for their antimicrobial, antitumor, antiviral, antineoplastic, and antioxidant properties, owing to their strong chelating ability. Probiotics refer to “live microorganisms that, when administered in adequate amounts, confer a health benefit on the host”. The goal of this research was to explore the abilities antibacterial, anticancer, and antioxidant effects of Schiff Bases N-methylene-N-phenylbenzenaminium and N-(5-oxopentylidene)-N-phenylbenzenaminium, as well as their impact regarding the properties of probiotics of Lactobacillus acidophilus and Lacticaseibacillus rhamnosus. The results indicate that these Schiff bases promote the growth of probiotic bacteria while inhibiting pathogenic bacteria. They demonstrate potent antibacterial and antioxidant activities, and cytotoxicity assays reveal that both compounds exert a high degree of inhibition on the human colon (HT-29 and Caco-2) and breast (MCF-7) cancer cells. Additionally, there is a notable rise or substantial growth in auto-aggregation and surface hydrophobicity of probiotic bacteria. In conclusion, the Schiff bases investigated in this study possess significant therapeutic potential.
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