Abstract
Aim: The essential protein element of spider silk 'spidroin' was usedto assess its impact on the wound-healing process. Methods: Spidroin nanoparticles (NPs) were prepared using poly(lactic-co-glycolic acid) polymer (PLGA/spidroin NPs) at different weight ratios (5:1, 10:1, 15:1) and were in vitro characterized. The optimized NPs were tested in vitro for release and antibacterial activity. To assess wound-healing effects, NPs were topically applied on surgically induced injuries in Allolobophora caliginosa earthwormsas a robust human skin model. Results: Optimized NPs (173±3nm) revealed considerable antibacterial effect against Staphylococcus aureus and Escherichiacoli. After 4days of NPs application on wounds, macroscopical and histological examinations revealed a significant reduction in wound and re-epithelialization times. Conclusion: PLGA/spidroin NPs may representa promising optionfor wound repair.
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