Abstract
Antibacterial and cytotoxic activities of supernatant and mycelium extracts from fermentation of fungal symbiont Trichoderma reesei TV221
Highlights
Marine sponges are marine organisms from the phylumPorifera whose life is in symbiosis with various microbes, including bacteria, cyanobacteria, microalgae, and fungi
Antibacterial and cytotoxic activity tests were carried out on the mycelium components from the fermentation of the T. reesei TV221 fungus and the growth curve of fungi fermented with seawater made from natural sea salt with a concentration of 30 ppt (3%) was determined
In this study, in obtaining the secondary metabolites from the T. reesei TV221 fungus, the fungal culture was fermented in liquid media of sabouraud dextrose broth (SDB) with seawater made from natural sea salt with a concentration of 30 ppt and fermented samples were taken every 2 days, followed by the determination of antibacterial and cytotoxic activity on the WiDr cancer cell line
Summary
Marine sponges are marine organisms from the phylumPorifera whose life is in symbiosis with various microbes, including bacteria, cyanobacteria, microalgae, and fungi. One of the sponge-associated fungi that have been researched and have antibacterial and cytotoxic activity is T. reesei TV221 (Setyowati et al, 2017, 2018a, 2018b). This fungus is a sponge-associated fungus from the Stylissa flabelliformis marine sponge from Menjangan Island, West Bali National Park. The extract from the fermentation of the T. reesei TV221 fungi associated with the S. flabelliformis sponge has antimicrobial activity against Staphylococcus aureus American Type Culture Collection (ATCC) 29213, Escherichia coli ATCC 25922, Candida albicans ATCC 10231, and methicillin-resistant S. aureus (Setyowati et al, 2017). According to the results of previous studies, the fungus T. reesei TV221 associated with the sponge S. flabelliformis could be developed as an antibacterial and anticancer agent
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