Antibacterial and Chemical Characterization of Silica-Quercetin-PEG Hybrid Materials Synthesized by Sol-Gel Route.

Vincenzo Arconati,Ignazio Blanco,Alberta Latteri,Michelina Catauro,Antonio D’Angelo,Veronica Viola,Gianluca Cicala

doi:10.3390/molecules27030979

Vincenzo Arconati, Ignazio Blanco + Show 5 more

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https://doi.org/10.3390/molecules27030979

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Abstract

This paper aims to synthesize, via the sol–gel method, a biomaterial usable in the medical field. Here, the silica-PEG-quercetin system was evaluated in relation to the different concentrations of PEG (0, 6, 12, 24, 50 wt%) and quercetin (0, 5, 10, 15 wt%), respectively. In addition, Fourier Transform-Infrared spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), and Kirby–Bauer analyses were performed. FT-IR was used to evaluate the hybrid formation and the influence of both PEG and Quercetin in the hybrid synthesized materials, SEM was used to evaluate the morphological properties, while the Kirby–Bauer test was used to understand the ability of the materials to inhibit the growth of the assayed bacterial strains (Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, and Staphylococcus aureus).

Highlights

Flavonoids are a varying group of natural substances, called phytonutrients
This paper aims to synthesize, via the sol–gel method, a biomaterial usable in the medical field
Molecules 2022, 27, 979 all the synthesized glassy hybrid biomaterials, obtained in the presence of quercetin, appear to be with a yellow or a light orange color (Figure 2C). This different color is due to the oxidation of the quercetin structure during the synthesis, which can be noticed by the differences that appear in the FT‐IR spectra of qsuynetrhcTeehstiiissn,dbwiefhffeiocrrheenctaancnodaloalsrfotiesbredthnueoetsitcyoendtthhbeeyostixhsiedcaodtniifodfneirteioonfncteh(sFetihgqauuterarecp3ept)ie.naInrsditnreuetchdteu, rFtehTed-IuCRr=isnOpgebcttahrnaed of the aorfyqlukeertcoentiincbgerfoourepa,nadssaifgtneredthetosy1n6t6h6ecsims c−1o,nsdhiitfitosnto(Faighuirgeh3e).rIwndaeveedn,uthmebCe=rO(1b7a3n9dcomf−1)

Summary

Introduction

Flavonoids are a varying group of natural substances, called phytonutrients They belong to a class of secondary metabolites having a polyphenolic structure, widely found in the plant kingdom. Quercetin is the main and the most thoroughly studied due to its anti-allergic, anti-bacterial, anti-oxidant, antiviral, anti-inflammatory, and anti-carcinogenic properties [1]. The beneficial properties of this compound are due to the chemical structure, especially for the presence and location of the hydroxyl (–OH) substitutions and the catechol-type B-ring. The presence of an ortho-dihydroxy or catechol group in the B-ring, a 2,3-double bond, and a hydroxyl substitution at positions 3 and 5 make quercetin a strong anti-oxidant, able to chelate metals and scavenge oxygen free radicals (Figure 1) [4,5]

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