Abstract
Problem Statement: Multiple drug resistance in human pathogenic micro organisms has developed due to indiscriminate use of modern antimicrobial drugs generally used in the management of infectious diseases. This increases the importance of exploiting the natural sources instead modern drugs. Approach: The antibacterial and antioxidant activity of different extracts from of Typhonium flagelliforme (L.) Blume tuber (family: Araceae) commonly called 'Rodent Tuber' was assessed towards selected bacteria as well as in different antioxidant models. The antibacterial screening was carried out by disc diffusion method. Two complementary test systems, namely DPPH free radical scavenging and total phenolic compounds, were used for the antioxidant analysis. Results: Except hexane extract none of the other extracts shown anti bacterial activity against the selected strains. The hexane extract from Typhonium flagelliforme tuber had interesting activity against both the gram negative bacteria, Pseudomonas aeruginosa (11±1.0 mm diameter) and Salmonella choleraesuis (12±1.1 mm diameter). The positive control, Streptomycin had shown zone of inhibition of 20±1.5 mm, 20±1.3 mm, 23±1.5 mm and 23±1.0 mm in Methicillin Resistant Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella choleraesuis and Bacillus subtilis respectively. All the extracts were subjected to screening for their possible antioxidant activity. The DPPH assay showed that the inhibitory activity of ethyl acetate (77.6±0.9%) and dichloromethane (70.5±1.7%) extracts were having comparatively admirable inhibition capacity when compared to the positive control BHT (95.3±1.3%). Total phenolic content of all extracts was also evaluated, and dichloromethane extracts (5.21±0.82 GAE mg/g extract) was superior to all other extracts, followed by hexane and ethyl acetate. Conclusion: Considering all the results collectively T. flagelliforme appears to be a promising plant demonstrating antibacterial and antioxidant activity that requires further investigation.
Highlights
Applications against human and animal pathogens, Medicine is used for treating diverse ailments. including bacteria, fungi and viruses[3,4]
Some of biological activities of T. flagelliforme tuber have been investigated, whereby; hexane, dichloromethane, ethyl acetate and methanol extracts of T. flagelliforme tuber were assayed for their antibacterial and anti-oxidant properties using disc diffusion method, DPPH assay and total phenolic compounds, respectively
Our findings showed that except hexane extract none of the other extracts shown any activity against the selected strains
Summary
Applications against human and animal pathogens, Medicine is used for treating diverse ailments. including bacteria, fungi and viruses[3,4]. Multiple drug resistance in human pathogenic micro organisms has developed due to indiscriminate use of commercial antimicrobial drugs commonly used in the treatment of infectious diseases. This situation has forced scientists to search for new antimicrobial substances from various sources as novel antimicrobial chemotherapeutic agents [9]. The occasionally beautiful and often bizarre combination of spathe and spadix called the inflorescence, sometimes referred to as a flower is a distinguishing feature of all aroids, which has been used for trapping their pollinators because of their particular morphology and organization of their inflorescences [11] This plant grows wild in wasteland and is native to the South East Asian countries and the southern part of India and Sri Lanka[12]. There are other practices where the leaves are wrapped in Longan flesh and taken raw[13]
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