Antibacterial and Antifungal Sesquiterpenoids from Aerial Parts of Anvillea garcinii.

Shagufta Perveen,Hanan Y. Aati,Afsar Khan,Areej M. Al-Taweel,Orazio Taglialatela-Scafati,Taghreed A. Ibrahim,Jawaher Alqahtani,Hasan S. Yusufoglu,Maged S. Abdel-Kader,Raha Orfali

doi:10.3390/molecules25071730

Abstract

Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia-11(13)en-12,6α-olide (1), and germacrane, 9β-hydroxyparthenolide-9-O-β-D-glucopyranoside (2), classes have been isolated from the leaves of the Saudi medicinal plant Anvillea garcinii along with seven known compounds (3–9). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of 1–9 were screened against seven different pathogenic microbes, and compounds 1–3 showed a potent antifungal activity.

Highlights

Traditional medicines are a powerful weapon for mankind and they have been used to treat several health disorders since ancient times
This richness of bioactive secondary metabolites prompted us to continue our phytochemical This richness of bioactive secondary metabolites prompted us to continue our phytochemical and biological investigation of A. garcinii, with the final aim of obtaining a detailed picture of the and biological investigation of A. garcinii, with the final aim of obtaining a detailed picture of the metabolome of this plant, providing solid scientific grounds for its use in traditional medicines and metabolome of this plant, providing solid scientific grounds for its use in traditional medicines and possibly, to develop a new phytotherapeutic drug from this natural source. In this manuscript we possibly, to develop a new phytotherapeutic drug from this natural source. In this manuscript we report the the isolation of twoofnew sesquiterpenoids belonging belonging to the guaiane report isolation two new sesquiterpenoids to (4α,9α,10α-trihydroxyguaiathe guaiane (4α,9α,10α11(13)en-12,6α-olide, (1))
(1–2) and seven known compounds (3–9) (Figure 1). The structures of these metabolites were were elucidated by spectroscopic analysis, mainly one-dimensional

Summary

Introduction

Traditional medicines are a powerful weapon for mankind and they have been used to treat several health disorders since ancient times. The last few decades have witnessed a renaissance in the use of natural products, and traditional medicine in general, to prevent or cure several ailments. While they are considered one of the possible options in several countries, they are practically the main therapeutic option in many developing countries, including those of the Arabian Peninsula. The dominating plant family is Asteraceae, one of the largest plant families on the planet, which is a family that includes more than one thousand genera and twenty thousand species [2]. Asteraceae plants are well known for their biological and pharmacological effects, largely ascribable to the presence of phytochemicals belonging to polyphenol, flavonoid, and terpenoid classes [3]

Methods

Discussion

Conclusion