Abstract
<i>Phyllanthus fraternus</i> Webster is a medicinally very useful plant species used by tribal of Gujarat, India to cure certain diseases like asthama, cough, diarrohea and scabies. Methanolic and ethanolic leaf extracts of the plant leaf were evaluated against eleven clinically important bacterial strains such as <i>E. coli, B. megaterium, B. cereus, B. subtilis, C. glutamicum, S. aureus, S. typhi, S. typhi A, S. typhi B, P. aeruginosa </i>and <i>P. vulgaris</i> and one fungal strain namely <i>A. niger</i> by disc diffusion method. Result showed maximum antibacterial activities against <i>C. glutamicum</i> with zone of inhibition of 40 mm and minimum against <i>S. typhi A</i> with zone of inhibition of 15 mm in methanol extract. In ethanol extract maximum antibacterial activities were reported in<i> Bacillus cereus </i>with zone of inhibition of 21 mm and minimum against <i>Salmonella typhi A </i>(10 mm).<i> </i>The maximum antifungal activity was noted against <i>A. niger</i> (40 mm). Our preliminary phytochemical analysis of leaf extract using Methanol as solvent confirmed the presence of alkaloids, tannin, saponin, terpenoid and steroids. This indicates that antimicrobial activities may be due to presence of secondary metabolites. Hence, the plant can be used to discover bioactive natural products that may serve as leads in the development of new pharmaceuticals research activities.
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