Abstract
This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015. Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed. The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.
Highlights
Antibacterials and antifungals are among the most commonly used drugs
It is possible that the main antibacterial and antifungal compounds of the marine fungal strains are from Aspergillacea are polyketides, but beyond that, it is difficult to find a correlation between the types of new compounds and the phylogeny of the marine fungi
To facilitate the discovery process, there are several methods to screen the marine fungi before further purification of their antimicrobial compounds
Summary
As the resistance of bacterial and fungal pathogens has become increasingly serious, there is a growing demand for new antibacterial and antifungal compounds. Natural products from fungi are considered an important source for novel antibacterial and antifungal compounds because of their abundant fungal species diversity, their rich secondary metabolites and the improvements in their genetic breeding and fermentation processes. The antimicrobial activities of an increasing number of fungi living in distinctive environments are being investigated for the discovery of new antibacterial and antifungal compounds, Mar. Drugs 2015, 13 such as endophytic fungi from wild plants and marine fungi. Many novel bioactive natural products from marine fungi have been discovered that possess cytotoxic, anticancer, antiviral, antibacterial or antifungal activities [1,2,3,4,5,6]. This paper reviews the antibacterial and antifungal compounds from marine fungi with specific focus on the period from January 2010 to March 2015
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