Abstract
Jatropha multifida (Ogege) sap was screened for antibacterial and antifungal activities against Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Salmonella typhi and Candidasp. The phytochemical components of Jatropha multifida (Ogege) sap showed the presence of alkaloids, saponin, carbohydrate, phenol and tannins, and the absence of glycosides, flavonoids and steroid. Agar well diffusion and broth dilution methods were used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) at concentrations 1050mg/ml to 2mg/ml (by two fold dilution using sterile distilled water). The result of this study showed that all the organisms were susceptible to the sap. Gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus were found most susceptible with MIC of 4mg/ml and 16mg/ml respectively, followed by Gram-negative bacteria, Pseudomonas aeruginosa, Escherichia coli and Salmonella typhi with MIC of 66mg/ml and Klebsiella pneumoniae, 263mg/ml, and Candidasp. had MIC of 263mg/ml. The MBC determination showed that a concentration of 131mg/ml and 263mg/ml could completely kill Staphylococcus aureus and Bacillus subtilis respectively and 525mg/ml could completely kill both Klebsiella pneumoniae and Candidasp. The result of this study suggests that Jatropha multifida (Ogege) sap could be potential source of new antimicrobial agents.
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