Antibacterial and anticancer activities of green-synthesized silver nanoparticles using Photinia glabra fruit extract.

Abstract

Aims: We prepared Photinia glabra (PG) aqueous fruit extract, utilized it to synthesize silver nanoparticles (PG-Ag NPs) and evaluated theantibacterial and anticancer activities of the nanoparticles (NPs). Materials & methods: Silver nitrate aqueous solution was reduced to PG-Ag NPs usingaqueous PGfruit extract. NP shape, size, composition and functionalization were determined using transmission electron microscopy, x-ray photoelectron spectroscopy, Fourier transform infraredand x-ray diffraction. Results & conclusions: PG-Ag NPs were spherical, approximately39-77 nm-sized, functionalized surfaces with notable antibacterial activity against both Escherichia coli and Staphylococcus aureus, with anMIC <30ug/ml and cytotoxicity toward esophageal cancer cells, with IC50 values less than20ug/ml. PG-Ag@rt NPs have been shown to bea potent antibacterial and anticancer agent, and their enriched particle surfaces can be conjugated with other compounds for multibiomedical applications.