Abstract
The multi-drug resistance (MDR) bacteria is a global health problem that causes high mortality every year. Therefore, novel antibacterial agents are needed from natural biological sources. This research aimed to investigate the antibacterial activities of various crude extracts of Averrhoa bilimbi against MDR bacteria. The antibacterial activity was calculated based on the use agar well diffusion assay and the minimum bactericidal concentration (MBC) using Mueller–Hinton broth in a microdilution method. Bacteria from wells were subcultured using inoculating loop onto a 5% sheep BAP. The best antibacterial activity, calculated as the most widely inhibitory zone and the smallest MBC values. The ethanolic extract showed antibacterial activity against the all MDR bacterial test in the agar well diffusion assay (10-14.5 mm inhibition diameter). The MBC of water extract against ESβL + CR Pseudomonas aeruginosa showed the best antibacterial activity (12.5 mg/mL). The fruit of bilimbi was shown to be potentially developed as antibacterial agents, especially for MDR strains. Further in vivo research and discovery of action mode are needed to shed light on their antibacterial effects. This study can provide new information about the benefits of bilimbi as a source of natural antibacterial againts MDR-bacteria
Highlights
Plants is a good source of antibacterial compounds, because of the variety and diversity of theThe antibiotic resistant bacterial strains have been chemical structures of the compounds contained a menace to public health globally
Averrrhoa bilimbi ti-drug resistant (MDR) bacterial strains remain a Linn. known as belimbing wuluh in serious cause of concern since they cause treatment Indonesia is one of the medicinal plants that is found failures and impose huge economic burdens especial- in tropical and subtropical countries and useful as a ly in developing countries (Ballani and Babby, 2016). medicine, such as antidiabetic (Ahmad et al, 2019), multi-drug resistance (MDR) bacteria are the main cause of severe complica- hepatoprotective (Dnyaneshwar et al, 2010), antitions in the therapies of contagious diseases and has cancer, and antithrombotic agent (Ali et al, 2014)
The extracts of bilimbi fruit can a global health problem caused by inappropriate use inhibit bacteria Escherichia coli ATCC 25922, Pseuof antibiotics
Summary
Plants is a good source of antibacterial compounds, because of the variety and diversity of the. The antibiotic resistant bacterial strains have been chemical structures of the compounds contained a menace to public health globally. Averrrhoa bilimbi ti-drug resistant (MDR) bacterial strains remain a Linn. Medicine, such as antidiabetic (Ahmad et al, 2019), MDR bacteria are the main cause of severe complica- hepatoprotective (Dnyaneshwar et al, 2010), antitions in the therapies of contagious diseases and has cancer, and antithrombotic agent (Ali et al, 2014). Become a serious problem that causes high mortality Research related to antibacterial activity of bilimbi every year (Mekes et al, 2019). The extracts of bilimbi fruit can a global health problem caused by inappropriate use inhibit bacteria Escherichia coli ATCC 25922, Pseuof antibiotics. Patients with infections caused by domonas aeruginosa ATCC 27853, Salmonella
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