Antibacterial Activity of Triterpenoid from The Leaves of Tahi Ayam (Lantana camara Linn)

Abstract

Tahi Ayam (Lantana camara Linn.) is known for its traditional medicinal purposes, can be used for treating various diseases. This is ascribed to the abundant presence of secondary metabolite compounds in Lantana camara Linn. In particular, the ethyl acetate extract of Lantana camara Linn. leaves contain secondary metabolite compounds belonging to the triterpenoid, steroid, coumarin, and phenolic groups. One of the triterpenoid compounds isolated from the ethyl acetate extract of Lantana camara Linn. leaves are 9-hydroxy-Lantadene A. Subsequently, an antibacterial test was conducted on this compound to assess its ability to inhibit the growth of test bacteria i.e. Staphylococcus aureus (Gram-positive) and Escherichia coli (Gramnegative). Amoxicillin was employed as a positive control. In addition to testing the antibacterial properties of the 9-hydroxy-Lantadene A compound, the ethyl acetate fraction of Lantana camara Linn. leaves also underwent the same antibacterial testing procedure. The results of this study suggest that both the isolated compound and the ethyl acetate fraction from Lantana camara Linn. leaves possess antibacterial activity. However, it's important to note that the antibacterial activity observed in both samples is relatively low. The possible cause of this could be the low sample concentrations utilized in the research