Abstract
Objective: This study sought to preliminarily investigate the inhibitory effect of metabolites of Aspergillus chevalieri and Trichoderma harzianum on a number of pathogenic bacteria.
 Methods: The agar well diffusion method was employed to determine the antimicrobial activity of the fungal metabolites. The test microorganisms were Enterococcus faecalis, methicillin-resistant Staphylococcus aureus (MRSA), Salmonella typhi, Escherichia coli and Pseudomonas aeruginosa. 
 Results: Both metabolites had broad-spectrum antibacterial activity. All the test organisms were susceptible to the A. chevalieri metabolites except for S. typhi. Both S. typhi and E. faecalis were however not susceptible to T. harzianum metabolites. P. aeruginosa was highly susceptible to both metabolites with the highest zone of inhibition of 26 mm for the stock metabolite. This activity was comparable to the standard, 10 µg/ml of ciprofloxacin.
 Conclusion: Metabolites of A. chevalieri and T. harzianum exhibited broad-spectrum activity, and this can be exploited as a source for novel antibiotics.
Highlights
Infectious diseases caused by bacteria, fungi, and protozoa are common and widespread
The metabolites from A. chevalieri inhibited the growth of S. typhi, and P. aeruginosa up to the 1 in 4 dilution
The 1 in 8 dilution of T. harzianum metabolite was active against E. coli and P. aeruginosa, while activity was seen against methicillin-resistant Staphylococcus aureus (MRSA) up to the 1 in 4 dilution, this metabolite was neither active against S. typhi nor E. faecalis
Summary
Infectious diseases caused by bacteria, fungi, and protozoa are common and widespread. They are the primary causes of morbidity, mortality, and a social and economic hindrance for millions of people [1]. The emergence of antimicrobial-resistant bacterial strains is increasingly limiting the potency of current drugs, and significantly causing treatment failures [5, 6]. This has necessitated the fervent need to search for new antibiotics from natural products [7, 8]. The discovery and development of the penicillins and cephalosporins from fungal sources, till date, remains some of the most important antibiotics [10] to humankind
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