Abstract
Cerium oxide nanoparticles have found numerous applications in the biomedical industry due to their strong antioxidant properties. In the current study, we report the influence of nine different physical and chemical parameters: pH, aeration and, concentrations of MgSO4, CaCl2, KCl, natural organic matter, fructose, nanoparticles and Escherichia coli, on the antibacterial activity of dextran coated cerium oxide nanoparticles. A least-squares quadratic regression model was developed to understand the collective influence of the tested parameters on the anti-bacterial activity and subsequently a computer-based, interactive visualization tool was developed. The visualization allows us to elucidate the effect of each of the parameters in combination with other parameters, on the antibacterial activity of nanoparticles. The results indicate that the toxicity of CeO2 NPs depend on the physical and chemical environment; and in a majority of the possible combinations of the nine parameters, non-lethal to the bacteria. In fact, the cerium oxide nanoparticles can decrease the anti-bacterial activity exerted by magnesium and potassium salts.
Highlights
Cerium oxide nanoparticles (CeO2 NPs) are amongst the most widely used rare earth compound finding applications in industrial and commercial products
In the current study we report the antibacterial activity of dextran coated NPs
The industrial applications includes its uses as a polishing agents [1], ultraviolet absorbing compound in sunscreen [2], solid electrolytes in solid oxide fuel cells [3], as a fuel additive to promote combustion and in automotive exhaust catalyst [4]
Summary
Cerium oxide nanoparticles (CeO2 NPs) are amongst the most widely used rare earth compound finding applications in industrial and commercial products. The industrial applications includes its uses as a polishing agents [1], ultraviolet absorbing compound in sunscreen [2], solid electrolytes in solid oxide fuel cells [3], as a fuel additive to promote combustion and in automotive exhaust catalyst [4]. It is in the biomedical industry CeO2 NPs is gaining much attention because of their antioxidant properties [5].
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