Abstract
Juliflorine, an alkaloid isolated from PROSOPIS JULIFLORA is shown to possess antibacterial activity. This activity was tested IN VITRO against six Gram positive and ten Gram negative bacteria at comparable concentrations of penicillin, streptomycin, erythromycin, sulphamethoxazole, ampicillin and tetracycline. Among Gram positive bacteria Juliflorine was found to be effective against STREPTOCOCCUS PYOGENES, STAPHYLOCOCCUS AUREUS, CORYNEBACTERIUM DIPHTHERIAE var. MITIS, C. HOFMANNI and BACILLUS SUBTILIS. STREPTOCOCCUS FAECALIS was found resistant to all antibiotics used except for ampicillin and Juliflorine. No significant inhibitory effect of Juliflorine was found against the species of SALMONELLA, SHIGELLA, PROTEUS, PSEUDOMONAS, KLEBSIELLA and ESCHERICHIA COLI.
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