Abstract
Abstract Introduction Nanoparticles and associations to calcium hydroxide can be used to increase antimicrobial activity. Objective To evaluate antibacterial activity against Enterococcus faecalis and pH of intracanal medications (IM) based on calcium hydroxide (CH) and zinc oxide (ZnO) micro- or nanoparticles, and their association with 0.4% chlorhexidine (CHX). Material and method Root canals from single-rooted human teeth were inoculated and incubated for 21 days. After sample (S1), the root canals were filled with the medications for 7 days and samples were collected immediately after medication (S2) and 7 days later (S3). Counting of CFU mL-1 was performed. Polyethylene tubes filled with the medications were used for the pH evaluation after 3, 7, 14 and 28 days. Data were submitted to ANOVA and Tukey tests (p<0.05). Result All IM promoted elimination of E. faecalis immediately after medication (S2). All the pastes promoted a similar pH increase. Conclusion CH/ZnO micro- or nanoparticles associated with CHX promoted greater bacterial reduction in the root canals and similar pH.
Highlights
Nanoparticles and associations to calcium hydroxide can be used to increase antimicrobial activity
E. faecalis biofilm induced in root canals for 21 days, allowed the propagation of the microorganisms into dentinal tubules and root canal system
In root canals contaminated with E. faecalis, Lucena et al.[17] verified that Calcium hydroxide (CH) was not effective in its elimination, in addition there was an increase in the percentage of bacterial viability from 26.3% to 55.8%
Summary
Nanoparticles and associations to calcium hydroxide can be used to increase antimicrobial activity. Objective: To evaluate antibacterial activity against Enterococcus faecalis and pH of intracanal medications (IM) based on calcium hydroxide (CH) and zinc oxide (ZnO) micro- or nanoparticles, and their association with 0.4% chlorhexidine (CHX). Conclusion: CH/ZnO micro- or nanoparticles associated with CHX promoted greater bacterial reduction in the root canals and similar pH. Calcium hydroxide is used as medication in teeth with pulp necrosis, promoting microorganism reduction in the RCS, favoring the endodontic treatment success[2]. Calcium hydroxide (CH) has antimicrobial effect, due to its dissociation into Ca+ and OH- ions, promoting an alkaline pH1,3 and interaction with the microorganism cell wall, and inactivating bacterial byproducts such as endotoxin[4,5,6]. Association of CH with chlorhexidine is indicated in primary and secondary endodontic infections, increasing antimicrobial
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