Antibacterial Activity of Different Concentrations of Date Vinegar in Comparison to Ciprofloxacin against Multidrug-Resistance Pseudomonas aeruginosa Isolated from Infected Burn

Abstract

Background: Despite recent advances in burns management and antimicrobial chemotherapy, infection continues to be a tricky in the burns. Treatment of a burn infection especially in case of multi-drug resistant Pseudomonas aeruginosa is a big challenge in clinics and needs novel strategies. Miscarriage of the current treatment strategies to control several cases of burns infections, the systemic and local toxicity that are produced by many topical antibiotics (especially in children), and the delay of healing caused by several antiseptics, make a strong motive to find effective and safe products. Aim: This study aimed to investigate the in vitro activity of different concentration of date vinegar against P. aeruginosa in comparison to the ciprofloxacin, one of the antibiotics used in the treatment of burns infection by using disk diffusion method and agar dilution MICs assay. Results and Conclusion: The disk diffusion method revealed that mean inhibition zone of date vinegar at 100%, 50%, 20%, 10% and 5% were (50.9 ±0.27) mm, (30.5 ±0.24) mm, (25.9 ±0.29) mm, (18.3±0.22) mm, and (9.2±0.25) mm respectively while ciprofloxacin has mean inhibition zone (8.95 ±2.25) mm and MICs (1.25%). So the conclusion was that date vinegar exerted a good in vitro antimicrobial activity against all tested isolates.