Abstract
Natural products from medicinal plants either as pure compounds or as standardized extracts provide unlimited opportunities for new drug leads because of the unmatched availability of chemical diversity. Begonia malabarica Lam. is one of the medicinally important herbs belonging to the family of Begoniaceae. It is reported that the leaves are used to treat respiratory infections, diarrhea, blood cancer and skin diseases. The whole plant possesses a variety of secondary metabolites. Isolation of such compounds will add more novel bioactive structures that are of interest to screen and select potential lead compounds to discover and develop drugs in the modern pharmaceutical sector. Against this backdrop, Begonia malabarica was extracted with various solvents and bioactive compounds were isolated using chromatographic techniques. One of the bioactive compounds isolated from it was colorless or pale yellow oily compound that is soluble in chloroform. The structure of the compound was elucidated as di-butyl phthalate with the help of spectral data such as FT-IR, MS, 1 H-NMR and 13C-NMR. This is the first report to the family of Begoniaceae. The compound is reported to have antibacterial and anticancer properties.
Highlights
Begonia malabarica L. is an important medicinal plant belonging to the family of Begoniaceae
Plant is rich with vitamin C and its juice is consumed for blood purification and for treating fever.[4]
The profile of column fractions was monitored by thin layer chromatography (TLC) using pre-coated TLC plate of silica gel 60 F254 (MERCK, Darmstadt, Germany) for 0.2 mm thickness to confirm the similarities of elutes
Summary
Begonia malabarica L. is an important medicinal plant belonging to the family of Begoniaceae. Consumption of boiled leaves is practiced to treat stomach ulcer, diarrhea, stomachache, respiratory problems, and skin diseases.[1] Leaves are used as wild edible by the Kani Tribe in Kanyakumari District of Tamil Nadu in India that contain high content of phenolic and flavonoid compounds and exhibit free radical scavenging activity.[2] Their counterparts in Tirunelveli District of Tamil Nadu consume leaves to treat venereal diseases and cool the body.[3] Plant is rich with vitamin C and its juice is consumed for blood purification and for treating fever.[4] Leaf juice with a pinch of salt is consumed to treat giddiness and leaf paste is applied to treat foot sores.[5] The secondary metabolites including terpenes, polyphenols, alkaloids and some glycodsides are largely responsible for the individual properties of the plants such as aroma, flavour, color and medicinal actions.[6]. Isolation of di-butyl phthalate is reported here for the first time to the family of Begoniaceae from Begonia malabarica by us
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