Abstract
INTRODUCTION: Essential oils can serve as novel sources of antibiotics for multidrug-resistant bacteria.METHODS: The multidrug-resistance profile of a Klebsiella aerogenes strain was assessed by PCR and sequencing. The antibacterial activity of Cinnamomum cassia essential oil (CCeo) against K. aerogenes was assessed by broth microdilution and time-kill methods. RESULTS: K. aerogenes showed high antibiotic resistance. The genes bla KPC-2, ampC, bla CTX-M-15, bla OXA-1, and bla TEM were present. CCeo exhibited an inhibitory effect with a minimum inhibitory concentration of 17.57 μg/mL. CONCLUSIONS: The antibacterial activity of CCeo makes it a potential candidate for treating carbapenem- and polymyxin-resistant K. aerogenes strains.
Highlights
Essential oils can serve as novel sources of antibiotics for multidrug-resistant bacteria
The antibacterial activity of Cinnamomum cassia essential oil (CCeo) against K. aerogenes was assessed by broth microdilution and time-kill methods
Sequencing allowed us to identify other metallo-β-lactamase genes, such as ampC, blaCTX-M-15, blaOXA-1, and blaTEM, which provide K. aerogenes with a wide range of resistance mechanisms, possibly capable of transferring related genes, leading to an increase resistance to antibiotics, making it very difficult to treat infections caused by this bacterial strain
Summary
Essential oils can serve as novel sources of antibiotics for multidrug-resistant bacteria. The antibacterial activity of Cinnamomum cassia essential oil (CCeo) against K. aerogenes was assessed by broth microdilution and time-kill methods. Conclusions: The antibacterial activity of CCeo makes it a potential candidate for treating carbapenem- and polymyxin-resistant K. aerogenes strains.
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