Abstract
Asparagus racemosus is a medical extensively used in traditional medicine for various disorders including its use in infectious. So far work has been done to identify its active constituents responsible for antiseptic folk use of this plant. In the current investigation, we have made an effort to identify its chemical constituents that might be partly responsible for antimicrobial properties. Extraction and isolation of plant extract lead to isolation of two nor-lignans and two steroidal triterpenes (compound 1 to 4). All compound showed considerable antibacterial activities against E. coli and S. aureus while no significant activity was observed against S. typhi . This study highlighted the potential of A. racemosus to be further explored as a source of bioactive natural products. DOI: http://dx.doi.org/10.3329/bjp.v9i1.16672 Bangladesh J Pharmacol 2014; 9: 1-3
Highlights
Asparagus racemosus is a climbing perennial herb
New but effective antibacterial agents are very crucial for prompt therapeutic management of bacterial infections
Various compounds isolated from A. racemosus showed considerable antibacterial activity against selected bacterial strains except S. typhi (Table I)
Summary
Asparagus racemosus is a climbing perennial herb. It has folk usage as a treatment for dyspepsia and gastric ulcers as well as being used as a galactogogue. Powdered plant material (16.2 kg) was macerated in distilled methanol for 72 hours, which was followed by filtration and evaporation at reduced pressure under vacuum using rotary evaporator at 40°C. This process was repeated four times that afforded crude methanolic extract (1.319 Kg). Sample was eluted initially with increasing polarity of n-hexane in combination with dichloromethane (DCM) ranging from 10%DCM in nhexane to 100%DCM.
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