Abstract
Objective: The objective of this research was to determine the antibacterial activity of the toothpaste from an extract of celery leaves on Streptococcusmutans.Methods: The toothpaste was formulated with various concentrations of celery leaves, F1 with concentration of extract (6.25%), F2 (12.5%), andF3 (25%). Each formula was tested the physical characteristics and antibacterial activity toward S. mutans. The antibacterial activity was determinedby the agar well diffusion method using brain heart infusion agar plates. Furthermore, the antibacterial activities were assessed by the presence orabsence of inhibition zones after the plates were incubated at 37°C for 24 h.Results: The results from this test illustrate that all toothpastes under study at various concentrations of celery leaves extract exhibited antibacterialactivity. Maximum inhibition zone in antibacterial activity test was shown by F2 (12.5%). Therefore, we can use these toothpastes as naturalantibacterial on prevention of dental caries caused S. mutans.Conclusion: The toothpaste from an extract of celery leaves showed significant antibacterial activity against S. mutans.
Highlights
MethodsThe toothpaste was formulated with various concentrations of celery leaves, F1 with concentration of extract (6.25%), F2 (12.5%), and F3 (25%)
Dental and oral diseases that are commonly found in Indonesia are dental caries
Majidah et al (2014) stated that celery leaves extract (Apium graveolens L.) at a concentration of 12.5% has an inhibitory effect on S. mutans [7]
Summary
The toothpaste was formulated with various concentrations of celery leaves, F1 with concentration of extract (6.25%), F2 (12.5%), and F3 (25%). Each formula was tested the physical characteristics and antibacterial activity toward S. mutans. The antibacterial activity was determined by the agar well diffusion method using brain heart infusion agar plates. The antibacterial activities were assessed by the presence or absence of inhibition zones after the plates were incubated at 37°C for 24 h
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