Antibacterial Activity of 2-[(2-Chloro-4-Methylbenzylidene) Amino] Pyridin-4-Ol and Its Some Transitional Metal Ion Complexes

Abstract

A new Schiff bases containing 2-((2-chloro-4-methylbenzylidene) amino) pyridin-4-ol with some transition metal ions with general formula of the complexes (M(L2)nH2O) ( where M= Mn(II), Co(II), Ni(II) Cu(II), Zn(II), Pt(II) and L= 2-((2-chloro-4-methylbenzylidene) amino) pyridin-4-ol ) have been synthesized and characterized by elemental analysis, molar conductance, magnetic moment and spectral techniques like Infrared spectra, Electronic Spectra, Mass Spectra, Thermal Analysis, Electron spin Resonance & X-ray powder diffraction. The complexes have six co-ordination numbers with octahedral geometry. The mass spectral data confirms the monomeric structure of the metal complexes, while Thermal studies confirm that presence of two co-ordinate water molecules in the complexes. The covalency factor (β), bonding parameter (b 1/2 ) suggest that complexes have covalent nature. The Schiff base and complexes have been tested against some bacteria, it shows that Pt (II) complexes are more active towards all bacteria. Keywords: 2-((2-chloro-4-methylbenzylidene) amino) pyridin-4-ol, ESR, TGA/DTA, Electronic spectra and Antibacterial activity.