Abstract
Pyrimidine derivatives have been in use since ages. Pyrimidine derivatives have shown wide range of pharmacological actions. However still many activities haven’t been researched so far. It is because of this reason the derivatives of the pyrimidine compounds was selected for the present study. In the present research work, it is all about the newer compounds being developed, designed, and experimented for their pharmacological actions. The current research shows the antibacterial activity tested in the new compounds designed in the laboratory. The antimicrobial activities were tested using agar plate and well diffusion method was especially selected for the present research work. Complete and proper steps were followed as per the guidelines. All precautions were taken while carrying out research for the derivative compounds in the present study. The designed compound showed effective and positive antibacterial activity present in the compound designed in the laboratory. Activity on both Gram positive and Gram negative microbes was tested, and the outcomes were in affirmation of the derivative compounds to be studied further for their pharmacological activities on both Gram positive and Gram negative microbes, and the outcomes were in affirmation of the derivative compounds to be studied further for their pharmacological activities for the derivative compounds selected in the present study. As a researcher, it is recommended to carry out further research on the same compound and being tested for other pharmacological activities.
Highlights
Medicinal chemistry is a chemistry-based discipline involving features of biological, medical and pharmaceutical sciences. It is concerned with the invention, discovery, design, and identification of biologically active compounds. It is concerned with the study of their metabolism, the interpretation of their mode of action at the molecular level, and the construction of their quantitative structural activity relationships (QSARs), which is the relationship between chemical structure and its pharmacological aspect [1]
With different heterocycle scaffolds the fusion of pyrimidine moieties produces new compounds of hybrid heterocycles which have highly enhanced action
Purines and pyrimidines are fused pyrimidines which by themselves are active from biological point of view and for some naturally occurring substrates they are very essential components such as nucleic acids
Summary
Medicinal chemistry is a chemistry-based discipline involving features of biological, medical and pharmaceutical sciences. It is concerned with the invention, discovery, design, and identification of biologically active compounds. The metabolism of the drug is an important object of study in the medicinal chemistry and considerable efforts needs to be spent on detailed analysis of bioconversions, a new drug series undergoes. Modern analytical methods such as mass spectrophotometery permit the identification of minute quantities of metabolites. The intellectual goal of the medicinal chemistry is to determine the mode of action
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