Abstract
Essential oils obtained by hydrodistillation of Montanoa quadrangularis leaves, flowers, and stems were analyzed by GC and GC/MS techniques revealing myrcene, limonene, β-phellandrene, and sabinene among the main components. The aim of the present study was to evaluate the MDR modulator activity on human MDR1 gene transfected mouse lymphoma cell line and the antimicrobial activity on the essential oils obtained from different parts of the species under investigation. The results revealed that MQL caused a similar increase in the fluorescence activity of the cells at 0.02 μL/mL comparing to the Verapamil® value. The antimicrobial assay was carried out according to the disc diffusion method. Five different bacterial strains (Staphylococcus epidermidis, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli AG 100, and Escherichia coli AG100A) were treated with the essential oils and the zones of inhibition were determined on TSA plates and TSA agar plates supplemented with Tween 20. MQF and MQL showed activity against B. subtilis, S. epidermidis, and E. coli AG 100A while MQS was only active against E. coli AG 100A on TSA agar plates experiment. In case of TSA agar plates supplemented with 0.1 v/v% Tween 20 detergent, MQF showed inhibition on B. subtilis, S. epidermidis, and E. coli AG 100A; MQL was active against B. subtilis, E. coli AG 100, and E. coli AG 100A while MQS was only active against E. coli AG 100A.
Highlights
The Asteraceae family comprises around 32,913 species distributed in 1911 genera and 13 subfamilies; it is considered one of the largest plant families around the world.Many species from the Asteraceae family have been used for medicinal purposes, since these have a wide range of biologically active compounds [1].Montanoa Cerv. in Llave & Lex genus belongs to Heliantheae tribe, Asteraceae Family, and is composed by 75 species found mainly in Mexico and Central America with five species endemics to northern South America [2,3,4]
The results showed that M. tomentosa induced dose-dependent anxiolytic-like actions in rats with low hormone level conditions [14]
Essential oils from fresh leaves (MQL), stems (MQS), and flowers (MQF) of Montanoa quadrangularis were analyzed by GC and GC/MS techniques
Summary
The Asteraceae family comprises around 32,913 species distributed in 1911 genera and 13 subfamilies; it is considered one of the largest plant families around the world.Many species from the Asteraceae family have been used for medicinal purposes, since these have a wide range of biologically active compounds [1].Montanoa Cerv. in Llave & Lex genus belongs to Heliantheae tribe, Asteraceae Family, and is composed by 75 species found mainly in Mexico and Central America with five species endemics to northern South America [2,3,4]. In Llave & Lex genus belongs to Heliantheae tribe, Asteraceae Family, and is composed by 75 species found mainly in Mexico and Central America with five species endemics to northern South America [2,3,4]. Species of this family are characterized by producing mainly sesquiterpenes, sesquiterpene lactones, acetylenic compounds, inulintype fructans, triterpenes, and flavonoids [1,5]. Montanoa quadrangularis is distributed through the tropical Andes from Colombia to Venezuela growing at altitudes between 1300 to 2800 m.a.s.l. In Venezuela, there are three well identified species; M. angulata Badillo, M. fragans Badillo, and M. quadrangularis
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