Abstract
The present work describes in vitro antibacterial activities and pharmacological effect of six mixed-ligand tris-chelates of copper(II) containing N-p-tolylpyridine-2-aldimine; 1,10-phenanthroline and 2,2'-bipyridine as neutral N,N-donors, towards some gram-positive and gram-negative bacterial strains in aqueous medium. All the six complexes have encouraging potentiality to inhibit the growth of some gram positive and gram negative bacteria and hence bacteriostatic agents. These copper(II) complexes were synthesized easily at room temperature by the novel silver(I) assisted trans-metallation reaction and kinetic study of the reactions suggest pseudo zero order. KEY WORDS: Copper(II)tris-chelates, Neutral N,N-donors, Bacteriostatic agent, Silver(I) assisted reaction, Kinetics study Bull. Chem. Soc. Ethiop. 2019, 33(3), 475-484.DOI: https://dx.doi.org/10.4314/bcse.v33i3.8
Highlights
Transition metal ions are known to play important roles in biological processes in humans [1, 2]
The synthesized copper(II) compounds have been tested for their in vitro anti-microbial activities against some pathogenic bacterial strains and promising results have been obtained
The bacterial strains used in this study were two Gram positive Bacillus subtilis 6633, Staphylococcus aureus and two Gram negative Escherichia coli K12 and Salmonella enterica ser. typhi SRC
Summary
Transition metal ions are known to play important roles in biological processes in humans [1, 2]. There are few reports regarding syntheses of mixed ligand tris-chelated copper(II) complexes of neutral N,N-donors in particular [11] due to pronounced Jahn-Teller distortions and to study their antimicrobial activities. The synthesized copper(II) compounds have been tested for their in vitro anti-microbial activities against some pathogenic bacterial strains and promising results have been obtained.
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