Abstract
The antibacterial activity of a traditional medicinal formulation also called “komi da ruwanka” used in the treatment of various diseases was assessed by agar well diffusion method. The formulations sampled from three different locations exhibited a significant (P<0.05) antibacterial activity against Staphylococcus aureus: (KAT1 15.67 ± 0.67, KAT2 15.00 ± 0.58 and KAT3 15.00 ± 0.58). There was no significant (P>0.05) antibacterial activity on Bacillus subtilis, Escherichia coli, Salmonella typhi and Shigella flexnerii. The content of the formulation was analysed by gas-chromatography coupled with mass spectrometry. Chlorobenzene (16.36%), P-xylene (13.77%), 1-methoxy-2-propyl acetate (11.49%) and toluene (11.39%) were identified as the major components. While methylligrocerate (0.16%), 3,5-Di-tert-butylphenol (0.37%), decane (0.45%), and dimethylglutarate (0.59%) as the minor components. The Nigerian traditional medicine system needs to be properly organized and should be incorporated within a regulatory frame work implemented at the federal level to ensure basic levels of standardization and quality control in the manufacture of traditional medicinal formulations.
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