Abstract
In this study, nanofibers with different ratios of poly(vinyl alcohol) and chitosan incorporated with moxifloxacin hydrochloride (MH/PVA/CS) were fabricated through the blending electrospinning, and the morphological features were tested using scanning electron microscopy (SEM). Further characterization of the new nanofiber was accomplished by Thermogravimetric analysis (TG), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). Antibacterial activity of the MH-loaded nanofibers at different drug loading were tested and compared with the blank group. Experimental results show that the MH/PVA/CS nanofibers exhibited the good antibacterial properties against Staphylococcus aureus and Pseudomonas aeruginosa due to the MH incorporation. Compared with blank nanofibers, MH/PVA/CS nanofibers have significantly better antibacterial properties, and different proportions of PVA and CS have a certain effect on the antibacterial activity of nanofibers. The conclusions in this paper show that MH/PVA/CS composite nanofibers may have great potential in antibacterial materials.
Highlights
Medical treatment often faces the dilemma of bacterial infection, which delay the cure or even worsen the disease (Fisher et al, 2017)
The previous study of Hang et al indicated that the concentration and conductivity of the prepared solution before electrospinning are key factors which effect the morphological characteristics of electrospun nanofibers (Hang et al, 2010)
Different content of chitosan affected the diameter of nanofiber, which indirectly led to the different drug content of the nanofibers. the specific effect was discussed in the Section Drug content and encapsulation efficiency
Summary
Medical treatment often faces the dilemma of bacterial infection, which delay the cure or even worsen the disease (Fisher et al, 2017). The development of antibacterial nanomaterials has effectively solved this problem, and related studies (Sonkusare et al, 2018; Chouke et al, 2019) have shown that it has positive effects in inhibit bacterial reproduction, reduce inflammation, wound healing and disease treatment. The antibacterial nanofibers were widely used in various fields due to high porosity and small pore size (Dinis et al, 2015), especially in tissue engineering, drug delivery and wound dressings of biomedical applications (Lee et al, 2016; Sun et al, 2017). Electrospun nanofibers with chitosan have unique advantages in biomedical applications since they mimic the natural extracellular matrix (ECM) as a structure to support and regulate cell behavior
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