Abstract
Objective: The present was initiated to study the antibacterial properties of the Crateva adansonii DC extract on germs commonly identified in skin and digestive infections in Benin as well as the reversion of resistance to these aforementioned germs. Method: The bacteria’s sensitivity test to extracts was carried out by the microdilution method in liquid medium as well as the MIC and the reversion of bacterial resistance. For the determination of the MBC, this technique is used coupled with spreading on agar medium. Results: The results show an antibacterial activity of the extract with MICs between 0.625 - 5 mg/ml. The CMB of Enterococcus faecalis ATCC 29212 is 2.5 mg/ml while that of Methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis CIP 8039 is 5 mg/ml. The reversion of bacterial resistance has shown a synergy of action between our extract and conventional antibiotics.
Highlights
Human societies across civilizations are very attached to the use of medicinal plants [1] whose effectiveness is in most cases poor of scientific evidence [2]
Plant Material These are exclusively samples of leafy stems of Crateva adansonii DC. ssp. adansonii harvested in Dassa-Zoumè in central Benin
Biological Material The microorganisms used in this study are reference strains, namely Escherichia coli (CIP 53126), Staphylococcus aureus (ATCC 6538), Staphylococcus epidermidis (CIP 8039), Staphylococcus aureus resistant to methicillin, Enterococcus faecalis (ATCC 29212), Pseudomonas aeruginosa (CIP 82118) and two hospital strains of urinary and digestive origin, Pseudomonas aeruginosa and Escherichia coli isolated from biological samples from the microbiology laboratory of the Center Hospitalier Universitaire National/Hubert Koutoukou Manga (CNHU/HKM)
Summary
Human societies across civilizations are very attached to the use of medicinal plants [1] whose effectiveness is in most cases poor of scientific evidence [2]. Despite this strong propensity for folk medicine coupled with recent advances in modern medicine, infectious diseases constitute a serious public health problem in view of their frequency and severity OCDE [5]. Crateva adansonii DC, of the capparidaceae family, is a medicinal plant used by traditional healers in Benin for multiple therapeutic virtues, notably antibacterial properties. It is used in the treatment of many conditions including abscesses, sores, bacterial infections, high blood pressure, diabetes and rheumatism
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