Abstract
BackgroundIn response to the propagation of bacteria resistant to many antibiotics also called multi-drug resistant (MDR) bacteria, the discovery of new and more efficient antibacterial agents is primordial. The present study was aimed at evaluating the antibacterial activities of seven Cameroonian dietary plants (Adansonia digitata, Aframomum alboviolaceum, Aframomum polyanthum, Anonidium. mannii, Hibiscus sabdarifa, Ocimum gratissimum and Tamarindus indica).MethodsThe phytochemical screening of the studied extracts was performed using described methods whilst the liquid broth micro dilution was used for all antimicrobial assays against 27 Gram-negative bacteria.ResultsThe results of the phytochemical tests indicate that all tested extracts contained phenols and triterpenes, other classes of chemicals being selectively present. The studied extracts displayed various degrees of antibacterial activities. The extracts of A. digitata, H. sabdarifa, A. polyanthum, A. alboviolaceum and O. gratissimum showed the best spectra of activity, their inhibitory effects being recorded against 81.48%, 66.66%, 62.96%, 55.55%, and 55.55% of the 27 tested bacteria respectively. The extract of A. polyanthum was very active against E. aerogenes EA294 with the lowest recorded minimal inhibitory concentration (MIC) of 32 μg/ml.ConclusionThe results of the present work provide useful baseline information for the potential use of the studied edible plants in the fight against both sensitive and MDR phenotypes.
Highlights
In response to the propagation of bacteria resistant to many antibiotics called multi-drug resistant (MDR) bacteria, the discovery of new and more efficient antibacterial agents is primordial
The results indicated that the plants extracts showed antibacterial activities at variable degrees against MDR bacteria, with minimal inhibitory concentration (MIC) values varying from 32 to 1024 μg/ml
Extracts of A. digitata displayed the most important spectrum of activity, its inhibitory effects being observed against 81.48% of the bacterial strains, followed by the extracts of H. sabdarifa (66.66%), A. polyanthum (62.96%), A. alboviolaceum (55.55%) and O. gratissimum (55.55%)
Summary
In response to the propagation of bacteria resistant to many antibiotics called multi-drug resistant (MDR) bacteria, the discovery of new and more efficient antibacterial agents is primordial. Even though pharmaceutical companies have produced a number of new antibacterials in the last years, resistance to these drugs has increased and has became a global concern [1]. The global emergence of multi-drug resistant (MDR) bacteria is increasingly limiting the effectiveness of current drugs and significantly causing treatment failure [2]. Among the potential sources of new agents, plants have long been investigated. Because, they contain many bioactive compounds that can be of interest in therapeutic. They contain many bioactive compounds that can be of interest in therapeutic Because of their low toxicity, there is a long tradition of using dietary plants in the treatment of infectious disease in Cameroonian folk medicine
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