Abstract
In our continuous interest to study the diversity of halogenated metabolites of Malaysian species of the red algal genus Laurencia, we examined the chemical composition of five populations of unrecorded Laurencia sp. A new brominated diterpene, 10-acetoxyangasiol (1), and four other known metabolites, aplysidiol (2), cupalaurenol (3), 1-methyl-2,3,5-tribromoindole (4), and chamigrane epoxide (5), were isolated and identified. Isolated metabolites exhibited potent antibacterial activities against clinical bacteria, Staphylococcus aureus, Staphylococcus sp., Streptococcus pyogenes, Salmonella sp. and Vibrio cholerae.
Highlights
Red algae of the genus Laurencia (Rhodomelaceae, Ceramiales) are known to be prolific sources of a wide variety of halogenated secondary metabolites, such as C15-acetogenins and C15, C20, andC30-terpenoids [1]
In the course of our chemical and biological investigation of Laurencia species from the coastal waters of Borneo (Malaysia), we reported the chemical composition of L. snackeyi (Weber-van Bosse) Masuda [2], L. similis Nam et Saito [3], and L. majuscula (Harvey) Lucas [4,5]
As part of the chemical analysis of the undescribed Laurencia species, we examined five populations of
Summary
Red algae of the genus Laurencia (Rhodomelaceae, Ceramiales) are known to be prolific sources of a wide variety of halogenated secondary metabolites, such as C15-acetogenins and C15-, C20-, and. In the course of our chemical and biological investigation of Laurencia species from the coastal waters of Borneo (Malaysia), we reported the chemical composition of L. snackeyi (Weber-van Bosse) Masuda [2], L. similis Nam et Saito [3], and L. majuscula (Harvey) Lucas [4,5]. Each specimen contained one halogenated metabolite, a total of five halogenated metabolites were isolated and identified These specimens yielded one new 10-acetoxyangasiol (1) and four known halogenated metabolites; aplysiadiol (2), cupalaurenol (3), 1-methyl-2,3,5-tribromoindole (4), and chamigrane epoxide (5). The structure of the new compound 10-acetoxyangasiol (1) was elucidated by spectral data. The structures of the known metabolites (2–5) were determined based on the comparison of spectral data to that of the published reports of Ojika et al [6,7], Ichiba and Higa [8] and Carter and Rinehart [9]. We describe the isolation and structure elucidation of these compounds and their antibacterial activities against clinical bacteria
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