Abstract
The present study was carried out to identify antibacterial and antioxidant characteristics of traditional aqueous extracts derived from three traditional Chinese medicinal plants ( Scutellaria baicalensis , Coptis chinensis and Sonchus oleraceus ). It was indicated that the S. oleraceus showed the highest antibacterial efficacy, especially against Staphylococcus aureus . The minimum inhibitory concentration (MIC) of the S. oleraceus was 5.0 mg/mL what was in correlation with the high total phenolic and flavonoid contents and CUPRAC value, and MIC of both S. baicalensis and C. chinensis was 7.5 mg/mL. The rational pH of the working S. oleraceus was acidic, while the other two preferred to neutral or alkaline environment. The reasonable preservation temperature of S. baicalensis should not beyond 60°C, while the other two below 90°C. Meanwhile, S. baicalensis had significant antioxidant activity with the highest CUPRAC and ·OH scavenging activity. These results had provided useful information on further drug discovery.
Highlights
Naturally derived products play an important role as a source of medicine (Rubio-Moraga et al, 2013)
The minimum inhibitory concentration (MIC) of S. baicalensis and C. chinensis extracts for E. coli were 7.5 mg/mL, and the diameter of inhibition zone (DIZ) values of S. baicalensis and C. chinensis were between 7.4 mm and 9.3 mm, 7.1 mm and 9.6 mm respectively
We firstly evaluated the anti-oxidant contents, anti-oxidant properties and antibacterial activities of three traditional Chinese medicinal extracts (S. baicalensis, C. chinensis and S. oleraceus) from China using water as solvent solution, and observed the effect of different pH value and temperature treatment on the antibacterial activity
Summary
Naturally derived products play an important role as a source of medicine (Rubio-Moraga et al, 2013). Chinese traditional medicinal plants are important parts of Traditional Chinese Medicine (TCM), which are antibacterial and antioxidant and may play a significant role in the prevention and treatment of many diseases, and are considerably used for thousands of years in China, but all over the world (Liu et al, 2012; Sun et al, 2014; Zhang and Su, 2014). Based on traditional claims for the treatment of various disorders, the present study selected 3 traditional Chinese medicinal plants Scutellaria baicalensis Georgi, Coptis chinensis Franch and Sonchus oleraceus, which are widely distributed in the in northern China to evaluate the in vitro antibacterial activities and their optimal service conditions in a systematic and consistent manner.
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