Abstract
Bioassay-guided investigation of the bark of Elaeocarpus parvifolius led to the isolation of three new ellagic acid derivatives, 4- O-methylellagic acid 3′-α-rhamnoside ( 2), 4- O-methylellagic acid 3′-(3″- O-acetyl)-α-rhamnoside ( 3), and 4- O-methylellagic acid 3′-(4″- O-acetyl)-α-rhamnoside ( 4) in addition to the known ellagic acid derivative, 4- O-methylellagic acid 3′-(2″,3″-di- O-acetyl)-α-rhamnoside ( 1). Their structures were elucidated on the basis of analysis of 1H NMR, 13C NMR, HMQC, HMBC and MS spectroscopic data. Compounds 1– 4 were evaluated for their growth-inhibitory effect on Babesia gibsoni in vitro. Compounds 2 and 4 showed very weak activity, while compounds 1 and 3 showed moderate activity, with IC 50 values of 28.5 and 52.1 μg/ml, respectively.
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