Antiatherosclerosis effect of pine nut oil in HCHF diet‐fed rats (959.12)

Abstract

The objective of this study was to determine the antioxidative and antiatherosclerosis effects of a pine nut oil on serum and abdominal aorta in high fat high cholesterol diet fed rats. 6 weeks old male Spraque‐Dawley rats were divided into 5 groups. First group was fed with normal diet (normal control group, ND), second group was fed with high cholesterol‐high fat diet (negative control group, HCHF), third group was fed with HCHF diet with simvastatin diet (positive control group, HCHFS), fourth group was fed with HCHF diet with pine‐nut oil 7% (HCHFP 7%), and fifth group was fed HCHF with pine‐nut oil 15% diet (HCHFP 15%) for 6 weeks. This study shows that harmful parameter such as liver thiobarbituric acid reactive substance (TBARS) level, fatty steak area of aorta and low‐density lipoprotein cholesterol (LDL‐c) concentration of HCHFP group lower than that of HCHF group and beneficial parameters such as paraoxonase activity and high‐density lipoprotein cholesterol (HDL‐c) concentration were higher in HCHFP group than that of HCHF group. Through these results, our studies suggest that pine‐nut oil ingestion prevents the oxidative stress and atherosclerosis via the improvement of serum lipoprotein and the inhibition of lipid oxidation.