Abstract
Background: Momordica charantia (Cucurbitaceae) is a plant, reported for its variety of ethnic medicinal uses and widely grown in Asia, Africa, and the Caribbean for its edible fruit. Objective: The present work has been planned to screen antiarthritic activity of fruit of the plant with the ethanolic and aqueous extracts. Materials and Methods: Fruit powder was successively extracted with ethanol (95%) and water using soxhlet extraction and subjected to phytochemical screening to identify different phytoconstituents. Ld50studies for both (ethanolic and aqueous) extracts were conducted up to the dose level of 2 g/kg by following OECD up and down method of guidelines No. 425. Antiarthritic activity was performed using formaldehyde, Freund's adjuvant-induced arthritis in rats, and Collagen-induced arthritis model in mice. Statistical analysis was performed using one-way analysis of variance followed by Dunnett's t-test. P Abbreviations Used: LD50: Lethal dose 50%, OECD: Organization for Economic and Co-operation Development, CMC: Carboxy Methyl Cellulose.
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