Abstract
Antiarrhythmic effects of drugs and its minimum antiarrhythmic plasma concentrations were examined using the canine digitalis arrhythmia model and compared with those data obtained using coronary ligation (J. Pharmacol. Exp. Ther. 223:801, 1982) and halothane adrenaline arrhythmia (J. Cardiovasc. Pharmacol. 5(3): 1983). Cumulative injections of ouabain every 20 min produced sustained ventricular arrhythmia when the total dose reached 70 to 90 mcg/kg. Antiarrhythmic drugs of class 1, 2 and 4 were injected intravenously. Those drugs which significantly suppressed the arrhythmic ratio (the number of ventricular beats/total heart rate) were judged as effective, and the minimum effective plasma concentrations were calculated using the experimentally derived concentration time curves. All the class 1 drugs were effective, and their concentrations (mcg/ml) were: disopyramide,1.7 ; procainamide,10.1 ; aprindine, 0.8-, lidocaine, 3-5; Phenytoin, 11.3; mexiletine, 1.8. Beta-blockers, except for propranolol with a high membrane stabilizing concentration of 1.7 mcg/ml, and Ca-blockers were not effective on this arrhythmia. Phenytoin was not selectively effective on this arrhythmia. Canine digitalis arrhythmia seems to be a good model to differentiate class 1 drugs from other classes of antiarrhythmic drugs.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
