Abstract
Lidocaine, quinidine and diphenylhydantoin proved ineffective in preventing pacer-induced ventricular fibrillation in dogs in which paired pacing was attempted after coronary artery ligation. p]Propranolol prevented ventricular fibrillation in 11 of 14 animals, but only in a dose (5 mg/kg) that significantly reduced heart rate and myocardial contractility. Bretylium (5 mg/kg) protected 9 of 10 dogs against pacer-induced ventricular fibrillation and produced none of the negative chronotropic and inotropic effects observed with propranolol. These data suggest that administration of bretylium before paired pacing may be of value in the cardiogenic shock-low output failure syndrome related to acute myocardial infarction in man.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
