Abstract
The effects of adenosine triphosphate (ATP) on cardiovascular responses to epinephrine were evaluated in dogs anesthetized with halothane. The dose of epinephrine required to induce arrhythmias averaged 1.05 +/- 0.52 microgram/kg/min. The dose of ATP required to abolish these arrhythmias averaged 1.64 +/- 0.67 mg/kg/min. ATP had not only an antiarrhythmic effect but also antagonized epinephrine-induced increases in heart rate, systemic vascular resistance, mean arterial blood pressure, and further increased cardiac index. ATP had, however, no significant effect on epinephrine-induced increases in myocardial contractility.
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